Don’Tale Mayes derailed a historic night in Andrei Arlovski’s career on Saturday when he took out the former heavyweight champion at UFC on ESPN 45.

Mayes (10-5 MMA, 3-3 UFC) registered the most notable win of his career thus far when he timed a huge punch that dropped and led to the stoppage of Arlovski (34-22 MMA, 23-16 UFC) at the UFC Apex in Las Vegas.

It was a competitive fight through the first and opening portions of the second round. Mayes found his range, however, and loaded up on a shot that got the job done in Arlovski’s 40th UFC fight – the second in history to hit that mark along with Jim Miller).

Check out the replay below (via Twitter):

Hit him with his favorite punch #UFCVegas74 pic.twitter.com/Vptw6WrenY

— UFC (@ufc) June 4, 2023

What a knockout by @LordKongMayes #UFCVegas74 pic.twitter.com/CWIEeUz83Z

— UFC (@ufc) June 4, 2023

With the win, Mayes snapped a two-fight losing skid and evened his octagon record. He praised proper conditioning through training camp, and the desire to beat someone of Arlovski’s stature.

Up-to-the-minute UFC on ESPN 45 results include:

• Don’Tale Mayes def. Andrei Arlovski via TKO (punches) – Round 2, 3:17
• John Castaneda def. Muin Gafurov via unanimous decision (29-27, 29-27, 29-27)
• Muhammad Naimov def. Jamie Mullarkey via TKO (punches) – Round 2, 2:59
• Elise Reed def. Jinh Yu Frey via unanimous decision (29-28, 29-28, 29-28)
• Da’Mon Blackshear def. Luan Lacerda TKO (punches) – Round 2, 3:54
• Philipe Lins def. Maxim Grishin via unanimous decision (29-28, 29-28, 30-27)

For more on the card, visit MMA Junkie’s event hub for UFC on ESPN 45.